TLR & Inflammatory Pathway Analysis

<!-- @page { margin: 2cm } P { margin-bottom:portfolio monitoring services. At IMGENEX, we
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Soluble mediators, interferons, cytokines andreading systems that we developed and validated
chemokines are expressed and developed in theby research as a mediator, particularly in the
framework of the cascade pro-inflammatoryinflammatory response.
because of the NF-kB activation or IRF.The recently introduced TLR / NF-kB stably
Knowledge of specific receptors activated, thetransfected cell lines, and other primary cells,
active channel and the mediator sets producedallowing the identification of certain TLRs and
provide valuable information on how to control theinflammatory signaling pathways by
response.measurements of mediator. Again, products like
The analysis of pro-inflammatory mediatorour IMGENEX cell lines, assays ActivELISA factors
produced sets can be measured in a variety ofsuch as TNF, IFN, and PGE2, flow cytometry
both qualitative and quantitative tests as part ofreagents for IC staining of mediators and inhibitors
our testing services.of peptide allow us to transfer our expertise to
IMGENEX staff have pioneered the developmentyour project requirements.Soluble mediators,
and commercialization of tests for the analysisinterferons, cytokines and chemokines are
and measurement of mediators, cytokines,expressed and developed in the framework of
chemokines and interferons. Some of thesethe cascade pro-inflammatory because of the
platforms include products intracellular flowNF-kB activation or IRF. Knowledge of specific
cytometry, bead arrays, ELISPOT and ICC. Thereceptors activated, the active channel and the
possibility of combining this extensive knowledgemediator sets produced provide valuable
and expertise is a natural complement to ourinformation on how to control the response.